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Philip E. Cryer, MD  The American Journal of Medicine 

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1 Death during Intensive Glycemic Therapy of Diabetes: Mechanisms and Implications 
Philip E. Cryer, MD  The American Journal of Medicine  Volume 124, Issue 11, Pages (November 2011) DOI: /j.amjmed Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure Potential mechanism of iatrogenic hypoglycemia-induced hypoglycemia-associated autonomic failure (HAAF) mediated sudden death in diabetes: cardiovascular HAAF causing reduced baroreceptor sensitivity and metabolic HAAF, leading to an episode of hypoglycemia that increases sympathoadrenal system activity, which triggers a fatal ventricular arrhythmia in the setting of reduced baroreflex sensitivity. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions


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