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Death during Intensive Glycemic Therapy of Diabetes: Mechanisms and Implications
Philip E. Cryer, MD The American Journal of Medicine Volume 124, Issue 11, Pages (November 2011) DOI: /j.amjmed Copyright © 2011 Elsevier Inc. Terms and Conditions
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Figure Potential mechanism of iatrogenic hypoglycemia-induced hypoglycemia-associated autonomic failure (HAAF) mediated sudden death in diabetes: cardiovascular HAAF causing reduced baroreceptor sensitivity and metabolic HAAF, leading to an episode of hypoglycemia that increases sympathoadrenal system activity, which triggers a fatal ventricular arrhythmia in the setting of reduced baroreflex sensitivity. The American Journal of Medicine , DOI: ( /j.amjmed ) Copyright © 2011 Elsevier Inc. Terms and Conditions
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