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Figure 1 Location of HLA variants known to be associated

Published byHilary Cummings Modified over 6 years ago

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Presentation on theme: "Figure 1 Location of HLA variants known to be associated"— Presentation transcript:

1 Figure 1 Location of HLA variants known to be associated
with anti-citrullinated protein autoantibody-positive rheumatoid arthritis risk Figure 1 | Location of HLA variants known to be associated with anti-citrullinated protein autoantibody-positive rheumatoid arthritis risk. Unconditional and conditional logistic regression using additive terms for each of the variants in the entire major histocompatibility complex (MHC) region have identified HLA-DRβ1 amino acid positions 11 (or 13), 71 (or 57), and 74, HLA-B amino acid position 9, HLA-DPβ1 amino acid position 9, and HLA-A amino acid position 77 to be associated with anti-citrullinated protein autoantibody-positive rheumatoid arthritis. These amino acid positions are highlighted in coloured spheres within the epitope-binding grooves of HLA molecules. Kim, K. et al. (2016) Update on the genetic architecture of rheumatoid arthritis Nat. Rev. Rheumatol. doi: /nrrheum

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