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What Is the Role of Injectables in the Modern Era of MS Treatment?

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Presentation on theme: "What Is the Role of Injectables in the Modern Era of MS Treatment?"— Presentation transcript:

1 What Is the Role of Injectables in the Modern Era of MS Treatment?

2

3 The "Platform Injectables"

4 IFNβ-1b: 11-Year Follow-Up of BENEFIT Trial in CIS

5 IM IFNβ-1a 15-Year Follow-Up: Mean EDSS

6 Long-Term Results With GA: 15-Year Open-Label Study

7 UK Multiple Sclerosis Risk-Sharing Scheme: 6 Years of Injectables

8 Injectables: Long-Term Safety

9 Strategies for Minimizing Injection-Site Reactions

10 ADVANCE: SC PegIFNβ-1a

11 GALA 3-Year Results: Efficacy of GA 40 mg/mL 3X Weekly

12 SC PegIFNβ-1a and GA 40 mg/mL 3X Weekly: Safety

13 Adherence With New Formulations of SC IFNβ-1a and GA

14 Using Injectables in Clinical Practice: Considerations

15 Importance of Injectables in the Treatment Armamentarium

16 Role of Platform Injectables: Lessons From Hypertension Management

17 Clinical Trials With Injectables: Applying Data to Today's MS Patients

18 Sequencing With Platform Injectables

19 CombiRx: IM IFNβ-1a Plus GA

20 SENTINEL: IM IFNβ-1a Plus Natalizumab

21 Combining Immunomodulators: Lessons From Rheumatoid Arthritis Management

22 Challenges in Developing Follow-On Products

23 IFNβ Plus Teriflunomide

24 TV-5010 Development: Short-Term Preclinical and Clinical Studies Did Not Raise Concerns

25 TV-5010 Development: Long-term Toxicology Studies Raised Concerns

26 Meeting the Challenges in Developing Follow-On Products: Regulatory Guidance

27 Conclusions

28 Abbreviations

29 Abbreviations (cont)

30 Abbreviations (cont)


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