1. Volume 137, Issue 1, Pages 341-349 (July 2009)
Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis 
Marco Domenicali, Paolo Caraceni, Ferdinando Giannone, Anna Maria Pertosa, Alessandro Principe, Andrea Zambruni, Franco Trevisani, Tiziano Croci, Mauro Bernardi 
Gastroenterology 
Volume 137, Issue 1, Pages (July 2009)
DOI: /j.gastro
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2. Figure 1
(A) Incidence of ascites in cirrhotic rats receiving 2-week treatment with vehicle (n = 10), R3 (n= 11), or R10 (n = 10). (B) Volume of ascites at the time of death in cirrhotic rats presenting decompensation after 2 weeks of treatment with vehicle (9 of 10), R3 (6 of 11), or R10 (1 of 10). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range.
Gastroenterology  , DOI: ( /j.gastro )
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3. Figure 2
(A) Daily sodium intake, (B) daily natriuresis, and (C) daily sodium balance, expressed as the average of seven 24-hour determinations performed during the first (left) and second (right) week of treatment in cirrhotic rats receiving vehicle (n = 10), R3 (n = 11), or R10 (n = 10). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

4. Figure 3
(A) MAP, (B) cardiac output (CO), and (C) PVR at the end of the 2-week treatment in cirrhotic rats receiving vehicle (n = 7), R3 (n = 7), or R10 (n = 7). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

5. Figure 4
Correlations (Pearson's test) between daily sodium balance evaluated on the day before the hemodynamic study and (A) MAP, (B) cardiac output (CO), and (C) PVR. Closed circles, vehicle; open circles, R3; open triangles, R10.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

6. Figure 5
Renal blood flow at the end of the 2-week treatment in cirrhotic rats receiving vehicle (n = 5), R3 (n = 5), or R10 (n = 5). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions

7. Figure 6
(A) Liver fibrosis score at the end of the 2-week treatment in cirrhotic rats receiving vehicle (n = 7), R3 (n = 7), or R10 (n = 7). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range. Kruskal–Wallis test showed a statistically significant difference between the groups (P = .048); results of Dunn's posttests are reported on the top of figure. (B) Representative histologic pictures of livers from a healthy rat and cirrhotic rats at the end of the 2-week treatment with vehicle, R3, or R10. Sirius red staining technique.
Gastroenterology  , DOI: ( /j.gastro )
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8. Figure 7
Protocol 2. Results of the SOTs (ie, UNaV as percent of the amount of sodium given with the load) in cirrhotic rats. Data are expressed as box plots showing the mean, 95% confidence interval (box), and range. Box plots with continuous lines report the results of SOTs performed in animals receiving a single acute administration of vehicle, R3, or R10. Faded box plots with dashed lines report the results of sodium overload tests performed 1 week earlier in the same animals.
Gastroenterology  , DOI: ( /j.gastro )
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9. Figure 8
Protocol 3. (A) Daily sodium intake, (B) daily natriuresis, and (C) daily sodium balance expressed as the average of seven 24-hour determinations performed during the first and second week of treatment in cirrhotic rats receiving rimonabant switched from R3 to R10 (n = 8) after the first week of treatment (left) or vice versa (n = 8) (right). Data are expressed as box plots showing the mean, 95% confidence interval (box), and range.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions