1. Volume 59, Issue 2, Pages 272-279 (February 2011)
Vardenafil Decreases Bladder Afferent Nerve Activity in Unanesthetized, Decerebrate, Spinal Cord–Injured Rats 
Delphine Behr-Roussel, Stephanie Oger, Stéphanie Caisey, Peter Sandner, Jacques Bernabé, Laurent Alexandre, Francois Giuliano 
European Urology 
Volume 59, Issue 2, Pages (February 2011)
DOI: /j.eururo
Copyright © 2010 European Association of Urology Terms and Conditions

2. Fig. 1
Determination of mean maximal bladder filling volume in a decerebrate, unanesthetized, spinal cord-injured rat. (A) Representative cystometrogram tracing and (B) its concomitant recording of bladder afferent nerve firing (BANF). (C) Close-up view of a cystometrogram tracing and its concomitant recording of BANF before receiving saline or vardenafil injection.
IVP=intravesical pressure.
European Urology  , DOI: ( /j.eururo )
Copyright © 2010 European Association of Urology Terms and Conditions

3. Fig. 2
(A) Relationship between bladder afferent nerve firing (BANF) and intravesical pressure (IVP) and infused volume during bladder filling with saline in decerebrate, unanesthetized, spinal cord–injured rats before receiving saline or vardenafil injection. (B) Effect of bladder filling with saline on BANF. Afferent spike rate is plotted against the bladder volume, which was divided into 10 equal parts for each rat. Afferent spike rate was then averaged for each part and expressed as a percentage of its resting value. Data are mean plus or minus standard error of the mean.
BFV=bladder filling volume.
European Urology  , DOI: ( /j.eururo )
Copyright © 2010 European Association of Urology Terms and Conditions

4. Fig. 3
Representative cystometrogram tracing and its concomitant recording of bladder afferent nerve firing (BANF) in a decerebrate, unanesthetized, spinal cord–injured rat after (A) vardenafil 1mg/kg or (B) saline intravenous injection.
European Urology  , DOI: ( /j.eururo )
Copyright © 2010 European Association of Urology Terms and Conditions

5. Fig. 4
Effect of vardenafil (VAR) 1mg/kg and saline intravenous injection on bladder compliance after submaximal filling of the bladder in unanesthetized, decerebrate, spinal cord-injured rats. Data are mean plus or minus standard error of the mean.
European Urology  , DOI: ( /j.eururo )
Copyright © 2010 European Association of Urology Terms and Conditions

6. Fig. 5
Effect of vardenafil 1mg/kg and saline intravenous injection on (A) amplitude and (B) frequency of nonvoiding contractions and (C) bladder afferent nerve firing after submaximal filling of the bladder in unanesthetized, decerebrate, spinal cord-injured rats. Data are mean plus or minus standard error of the mean.
***p<0.001, two-way analysis of variance.
#p<0.05.
##p<0.01.
###p<0.001, Bonferroni’s post hoc analysis.
European Urology  , DOI: ( /j.eururo )
Copyright © 2010 European Association of Urology Terms and Conditions