1. The Sum of All Browning in FGF21 Therapeutics
Paul Lee, Michael M. Swarbrick, Jerry R. Greenfield 
Cell Metabolism 
Volume 21, Issue 6, Pages (June 2015)
DOI: /j.cmet
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematic Diagram Illustrating Interplay between Central/Peripheral FGF21 Actions, Thermogenesis, iBAT, and igWAT
The efficacy of FGF21 therapeutics is mediated via (1) UCP1-dependent thermogenesis (i.e., igWAT browning + re-browning of whitened iBAT resulting in overall boosting of whole-body BAT function), (2) UCP1-independent thermogenesis (e.g., stimulation of multi-organ mitochondrial biogenesis and PGC-1α enrichment), and (3) central nervous system (CNS) mechanisms.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2015 Elsevier Inc. Terms and Conditions