1. Has the T cell bitten off more than it can chew?
by Gordon Cook
Blood
Volume 120(10):
September 6, 2012
©2012 by American Society of Hematology

2. Intercellular transfer of tumor-derived HLA-G and CD86 proves immune-tolerogenic in myeloma.
Intercellular transfer of tumor-derived HLA-G and CD86 proves immune-tolerogenic in myeloma. Malignant plasma cells in myeloma induce immune dysfunction by directly inhibiting activation of T cells and dendritic cells as well as indirectly through inducing regulatory T cells. In addition to soluble factors, physical contact including trogocytosis can mediate immune suppression. Professional illustration by Paulette Dennis.
Gordon Cook Blood 2012;120:
©2012 by American Society of Hematology