1. Strategies to Induce Immunogenicity in Microsatellite Stable Colorectal Cancer

2. Early studies evaluating role of immune infiltrate in colorectal cancer

3. Tumors with high CD45RO+ associated with absence of lymphovascular and perineural invasion

4. Longer OS and DFS among patients with high density CD45RO+ cells

5. CD8+ and CD45+ cell densities predict OS and DFS in CRC

6. Does Immune Therapy Work in Colorectal Cancer?

7. PD-1 Blockade is Effective in MMR-D Colorectal Cancer

8. PD-1 Blockade significantly improves OS and PFS in MMR-D CRC compared to MMR-P CRC

9. Total somatic mutations per tumor in MMR-D v MMR-P tumors

10. Increased density of CD8+ T cells in tumor and invasive front in MMR-D cohort

11. Increased density of PD-L1 expression and CD8 T cells in tumor and invasive front in MMR-D cohort

12. PD-1 Blockade alone is ineffective in MMR-P CRC

13. Reasons for lack of response in MSS colon cancer

14. How do we make CRC make more “immunogenic”

15. Ad-CEA Vaccine

16. ETBX-011: Phase 1/2 Clinical Trial in Colorectal Cancer

18. Preclinical Model: MC38 C57BL/6 mice

19. Combination of MSB0010718C with 5-FU and Oxaliplatin

22. Treatment Schema

23. Endpoints and Statistical considerations

24. Future Directions

25. Acknowledgements