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Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception  Jasmine R. Dickinson, Grégory Scherrer  Neuron 

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Presentation on theme: "Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception  Jasmine R. Dickinson, Grégory Scherrer  Neuron "— Presentation transcript:

1 Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception  Jasmine R. Dickinson, Grégory Scherrer  Neuron  Volume 86, Issue 1, Pages 4-6 (April 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 A Speculative Model of ACC-Enhanced Dendritic Integration and Rescue during Chronic Pain (A) Pain neural pathways. ACC, anterior cingulate cortex; IC, insular cortex; S1, primary somatosensory cortex; S2, secondary somatosensory cortex; PFC, prefrontal cortex; PAG, periaqueductal gray; RVM, rostral ventromedial medulla. (B) Nerve injury reduces Ih, leading to enhanced temporal summation at the soma and increased nociception. (C) 5-HT7 agonism at distal dendrites increases cAMP levels which restores Ih and normal temporal summation, reducing injury-induced hypersensitivity. Neuron  , 4-6DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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