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Investigation of the mechanism of alcohol-induced bronchial asthma

Published byVictoire St-Pierre Modified over 6 years ago

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Presentation on theme: "Investigation of the mechanism of alcohol-induced bronchial asthma"— Presentation transcript:

1 Investigation of the mechanism of alcohol-induced bronchial asthma
Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Atsuko Takao, MDa, Chizu Fujiwara, MDa, Hiroto Matsuse, MDa, Hiroyuki Sakai, MDa, Takashi Watanabe, MDa, Kohei Hara, MDa, Sadahiro Asai, MDb  Journal of Allergy and Clinical Immunology  Volume 97, Issue 1, Pages (January 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 FIG. 1 Peak percent change in FEV1 after ethanol challenge.
Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 FIG. 2 Serial changes in FEV1 after ingestion of ethanol.
Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 FIG. 3 Mean change in blood ethanol concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 FIG. 4 Mean change in blood acetaldehyde concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 FIG. 5 Mean change in blood histamine concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 FIG. 6 Leukocyte histamine release induced by ethanol (2, 10, 20, and 100 mmol/L). Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 FIG. 7 Leukocyte histamine release induced by acetaldehyde (2, 10, 20, and 100 μmol/L). Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 FIG. 8 IgE antibodies specific for acetaldehyde-HSA. O.D., Optical density. Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

11 FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

12 FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology  , 74-84DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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