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Utility of a Simple Algorithm to Grade Diastolic Dysfunction and Predict Outcome After Coronary Artery Bypass Graft Surgery  Madhav Swaminathan, MD, Alina.

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Presentation on theme: "Utility of a Simple Algorithm to Grade Diastolic Dysfunction and Predict Outcome After Coronary Artery Bypass Graft Surgery  Madhav Swaminathan, MD, Alina."— Presentation transcript:

1 Utility of a Simple Algorithm to Grade Diastolic Dysfunction and Predict Outcome After Coronary Artery Bypass Graft Surgery  Madhav Swaminathan, MD, Alina Nicoara, MD, Barbara G. Phillips-Bute, PhD, Nicolas Aeschlimann, MD, Carmelo A. Milano, MD, G. Burkhard Mackensen, MD, PhD, Mihai V. Podgoreanu, MD, Eric J. Velazquez, MD, Mark Stafford-Smith, MD, Joseph P. Mathew, MD  The Annals of Thoracic Surgery  Volume 91, Issue 6, Pages (June 2011) DOI: /j.athoracsur Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Algorithms used for grading diastolic dysfunction. For abnormal grades of diastolic dysfunction (grades 1 to 3), algorithm A included all indicated variables whereas algorithm B included only those within the shaded area. (A = transmitral diastolic A wave; Adur = transmitral A-wave duration; Ardur = pulmonary vein flow A reversal wave duration; DT = E-wave deceleration time; E = transmitral early wave; e' = lateral mitral annular early diastolic tissue velocity; TDI = tissue Doppler imaging.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Survival curves for major adverse cardiac events (MACE) are shown using the Kaplan-Meier method for patients grouped according to grade of diastolic dysfunction using algorithm A. An additional survival curve shows lower MACE-free survival for patients unable to be assigned a grade with this algorithm (uncategorized). Overall p value for comparing the categorized groups is not significant (p = 0.079). However, the uncategorized group shows significantly lower MACE-free survival compared with categorized patients (p = 0.005). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Survival curves for major adverse cardiac events (MACE) are shown using the Kaplan-Meier method for patients grouped according to grade of diastolic dysfunction using algorithm B. Worsening diastolic dysfunction is significantly associated with decreased MACE-free survival (overall p value for comparison of categorized groups is significant at 0.01). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

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