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Clinical and Translational Radiation Oncology
Association of lung fluorodeoxyglucose uptake with radiation pneumonitis after concurrent chemoradiation for non-small cell lung cancer Jinbo Yue, Matthew McKeever, Terence T. Sio, Ting Xu, Jinhai Huo, Qiuling Shi, Quynh-Nhu Nguyen, Ritsuko Komaki, Daniel R. Gomez, Tinsu Pan, Xin Shelley Wang, Zhongxing Liao Clinical and Translational Radiation Oncology Volume 4, Pages 1-7 (June 2017) DOI: /j.ctro Copyright © 2017 The Authors Terms and Conditions
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Fig. 1 PET/CT fusion scans from a patient showing inflammatory infiltration of the lungs, with interstitial infiltrates, ground glass opacities, homogeneous consolidation, and patchy consolidation. (A) Scan obtained before treatment; the bright yellow area inside the white outline is the primary lung tumor. (B) Scan obtained 2months after treatment; the bright yellow area inside the white outline represents interstitial infiltrates. Scans obtained at 4months (C), 7months (D), and 10months after treatment (E) illustrate the course of interstitial infiltration over time. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: ( /j.ctro ) Copyright © 2017 The Authors Terms and Conditions
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Fig. 2 Longitudinal correlations between SUV variables and radiation pneumonitis (RP). All four variables studied [(A) SUVmax, (B) SUVpeak, (C) SUVmean, and (D) global lung glycolysis {GLG}] showed significant correlations with RP of grade 0–1 and 2–3 during the first 6months after therapy, but not thereafter. All four of these variables were higher in patients with CTCAE RP grade≥2 than in patients with CTCAE RP 0–1 during the first 6months after treatment, but not thereafter. Abbreviations: SUV, standardized uptake value; GLG, global lung glycolysis; CTCAE, Common Terminology Criteria for Adverse Events version 3; post 1, 1–3months after treatment; post 2, 4–6months after treatment; post 3, 7–9months after treatment; post 4, 10–12months after treatment. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: ( /j.ctro ) Copyright © 2017 The Authors Terms and Conditions
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Fig. 3 Cumulative probabilities of developing grade 0, 1, 2, or 3 radiation pneumonitis (RP) according to FDG uptake variables on PET. Panels A and B, SUVmean; panels C and D, SUVmax; panels E and F, SUVpeak; panels G and H, global lung glycolysis. Abbreviations: SUV, standardized uptake value; post1, 1–3months after treatment; post2, 4–6months after treatment. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: ( /j.ctro ) Copyright © 2017 The Authors Terms and Conditions
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