1. Cells reproduce by cell division.
One cell gives rise to two or more cells, called daughter cells. (Virchow)
Each daughter cell receives a complete set of heredity information—identical to the information in the parent cell—and about half of the cytoplasm.

2. Cell division transmits hereditary information to each daughter cell.
The hereditary information in each cell is deoxyribonucleic acid (DNA).
DNA is contained in chromosomes.
A molecule of DNA consists of smaller subunits called nucleotides.

3. The structure of DNA Fig. 8-1 phosphate nucleotide base T A A sugar C
A single strand of DNA
(b)
The double helix
Fig. 8-1

4. The eukaryotic chromosome consists of DNA bound to protein.
Human chromosomes contain a single DNA double helix that is 50 to 250 million nucleotides long, which would be about 3 inches long if the DNA were completely relaxed.

5. The nucleotides are held together by hydrogen bonding between the bases in two strands, called a double helix, which looks like a twisted ladder.
James Watson and Francis Crick combined the X-ray data with bonding theory to deduce the structure of DNA

6. DNA is composed of four nucleotides
DNA is made of chains of small subunits called nucleotides
Each nucleotide has three components
A phosphate group
A deoxyribose sugar
One of four nitrogen-containing bases
Thymine (T)
Cytosine (C)
Adenine (A)
Guanine (G)

7. The structure of DNA Fig. 8-1 phosphate nucleotide base T A A sugar C
A single strand of DNA
(b)
The double helix
Fig. 8-1

8. Hydrogen bonds between complementary bases hold two DNA strands together in a double helix (continued)
Because of their structures and the way they face each other, adenine (A) bonds only with thymine (T) and guanine (G) bonds only with cytosine (C)
Bases that bond with each other are called complementary base pairs
Thus, if one strand has the base sequence CGTTTAGCCC, the other strand must have the sequence GCAAATCGGG

9. The parental DNA is unwound Parental DNA double helix New DNA strands
are synthesized with
bases complementary
to the parental
strands
Each new double helix is composed
of one parental strand (blue) and one
new strand (red)

10. Segments of different lengths along a DNA molecule are the units of inheritance called genes.
Each gene spells out the instructions for making the proteins of the cell.
When a cell divides, it first replicates its DNA, and each copy is transferred into each daughter cell.

11. gene loci a pair of homologous chromosomes
Both chromosomes carry the same allele
of the gene at this locus; the organism
is homozygous at this locus
gene loci
This locus contains another gene for
which the organism is homozygous
Each chromosome carries a different
allele of this gene, so the organism is
heterozygous at this locus
the chromosome
from the male
parent
the chromosome
from the female
parent 11

12. Homologous chromosomes carry the same kinds of genes for the same characteristics
Genes for the same characteristic are found at the same loci on both homologous chromosomes
Genes for a characteristic found on homologous chromosomes may not be identical
Alternative versions of genes found at the same gene locus are called alleles

13. a pair of homologous chromosomes
Both chromosomes carry the same allele
of the gene at this locus; the organism
is homozygous at this locus
gene loci
This locus contains another gene for
which the organism is homozygous
Each chromosome carries a different
allele of this gene, so the organism is
heterozygous at this locus
the chromosome
from the male
parent
the chromosome
from the female
parent 13

14. An organism’s two alleles may be the same or different
Each cell carries two alleles per characteristic, one on each of the two homologous chromosomes
If both homologous chromosomes carry the same allele (gene form) at a given gene locus, the organism is homozygous at that locus
If two homologous chromosomes carry different alleles at a given locus, the organism is heterozygous at that locus (a hybrid)

15. a pair of homologous chromosomes
Both chromosomes carry the same allele
of the gene at this locus; the organism
is homozygous at this locus
gene loci
This locus contains another gene for
which the organism is homozygous
Each chromosome carries a different
allele of this gene, so the organism is
heterozygous at this locus
the chromosome
from the male
parent
the chromosome
from the female
parent 15

16. Unlike prokaryotic chromosomes, eukaryotic chromosomes are separated from the cytoplasm by a membrane-bound nucleus.
Eukaryotic cells always have multiple chromosomes.
Eukaryotic chromosomes contain more DNA than prokaryotic chromosomes.

17. Eukaryotic chromosomes usually occur in pairs (continued).
The nonreproductive cells of many organisms have chromosomes in pairs, with both members of the pair being the same length.
The chromosomes are the same length and have the same staining properties because they have the same genes arranged in the same order.

18. Eukaryotic chromosomes usually occur in pairs.
sex chromosomes
Eukaryotic chromosomes usually occur in pairs.
An entire set of stained chromosomes from a single cell is called a karyotype.
Fig. 8-6

19. Diploid cells contain 2n chromosomes.
The number of different types of chromosomes in a species is called the haploid number and is designated n.
In humans, n = 23.
Diploid cells contain 2n chromosomes.
Humans body cells contain 2n = 46 (2 x 23) chromosomes.

20. A typical human cell has 23 pairs of chromosomes.
22 of these pairs have a similar appearance and are called autosomes.
Human cells also have a pair of sex chromosomes, which differ from each other in appearance and in genetic composition.
Females have two X chromosomes.
Males have one X and one Y chromosome.

21. Eukaryotic chromosomes usually occur in pairs.
sex chromosomes
Eukaryotic chromosomes usually occur in pairs.
An entire set of stained chromosomes from a single cell is called a karyotype.
Fig. 8-6

22. There are two types of division in Eukarytic cells: mitotic cell division and meiotic cell division.
Mitotic cell division may be thought of as ordinary cell division, such as occurs during development from a fertilized egg, during asexual reproduction, and in skin, liver, and the digestive tract every day.
Meiotic cell division is a specialized type of cell division required for sexual reproduction.

23. Meiotic cell division
Meiosis

24. Cell division is required for sexual and asexual reproduction.
Sexual reproduction in eukaryotic organisms occurs when offspring are produced by the fusion of gametes (sperm and eggs) from two adults.
Gametes are produced by meiotic cell division, (Meiosis which results in daughter cells with exactly half of the genetic information of their parent cells).
Fertilization of an egg by a sperm results in the restoration of the full complement of hereditary information in the offspring.

25. Mitotic cell division
Mitosis

26. Reproduction in which offspring are formed from a single parent, without having a sperm fertilize an egg, is called asexual reproduction.
Asexual reproduction produces offspring that are genetically identical to the parent.
Examples of asexual reproduction occur in bacteria, single-celled eukaryotic organisms, multicellular organisms such as Hydra, and many trees, plants, and fungi.

27. Cell division is required for growth and development.
Cell division in which the daughter cells are genetically identical to the parent cell is called Mitotic cell division.
After cell division, the daughter cells may grow and divide again, or may differentiate, becoming specialized for specific functions.
The repeating pattern of division, growth, and differentiation followed again by division is called the cell cycle.

28. Duplicated chromosomes separate during cell division.
Prior to cell division, the DNA within each chromosome is replicated.
The duplicated chromosomes then consist of two DNA double helixes and associated proteins that are attached to each other at the centromere.

29. Eukaryotic chromosomes during cell division
centromere
genes
duplicated chromosome (2 DNA double helices)
sister chromatids
(a)
A replicated chromosome consists of two sister chromatids
independent daughter chromosomes, each with one identical DNA
double helix
(b)
Sister chromatids separate during cell division
Fig. 8-5

30. Duplicated chromosomes separate during cell division (continued).
Each of the duplicated chromosomes attached at the centromere is called a sister chromatid.
During mitotic cell division, the sister chromatids separate and each becomes a separate chromosome that is delivered to one of the two resulting daughter cells.

31. Eukaryotic chromosomes during cell division
centromere
genes
duplicated chromosome (2 DNA double helices)
sister chromatids
(a)
A replicated chromosome consists of two sister chromatids
independent daughter chromosomes, each with one identical DNA
double helix
(b)
Sister chromatids separate during cell division
Fig. 8-5

32. Eukaryotic cell cycle

33. Meiotic cell division
Meiosis

34. Cell division is required for sexual and asexual reproduction.
Sexual reproduction in eukaryotic organisms occurs when offspring are produced by the fusion of gametes (sperm and eggs) from two adults.
Gametes are produced by meiotic cell division, (Meiosis which results in daughter cells with exactly half of the genetic information of their parent cells).
Fertilization of an egg by a sperm results in the restoration of the full complement of hereditary information in the offspring.

35. Mitotic cell division
Mitosis

36. Mitotic cell division
Mitotic cell division consists of nuclear division (called mitosis) followed by cytoplasmic division (called cytokinesis) and the formation of two daughter cells.

37. The eukaryotic cell cycle is divided into two major phases: interphase and cell division.
During interphase, the cell acquires nutrients from its environment, grows, and duplicates its chromosomes.
During cell division, one copy of each chromosome and half of the cytoplasm are parceled out into each of two daughter cells.

38. Mitosis is divided into four phases.
Prophase
Metaphase
Anaphase
Telophase

40. Prophase
Fig. 8-9b–c

41. Three major events happen in prophase:
During prophase, the chromosomes condense and are captured by the spindle microtubules.
Three major events happen in prophase:
The duplicated chromosomes condense.
The spindle microtubules form.
The chromosomes are captured by the spindle.

42. The centriole pairs migrate with the spindle poles to opposite sides of the nucleus.
When the cell divides, each daughter cell receives a centriole.
Every sister chromatid has a structure called a kinetochore located at the centromere, which attaches to a spindle apparatus.

43. Prophase
Fig. 8-9b–c

44. Metaphase
Fig. 8-9d

45. During metaphase, the chromosomes line up along the equator of the cell.
At this phase, the spindle apparatus lines up the sister chromatids at the equator, with one kinetochore facing each cell pole.

46. Metaphase
Fig. 8-9d

47. Anaphase
Fig. 8-9e

48. During anaphase, sister chromatids separate and move to opposite poles of the cell.
Sister chromatids separate, becoming independent daughter chromosomes.
The kinetochores pull the chromosomes poleward along the spindle microtubules.

49. Anaphase
Fig. 8-9e

50. Telophase
Fig. 8-9f

51. During telophase, nuclear envelopes form around both groups of chromosomes.
Telophase begins when the chromosomes reach the poles.
The spindle microtubules disintegrate and the nuclear envelop forms around each group of chromosomes.

52. Telophase
Fig. 8-9f

53. Cytokinesis
Fig. 8-9g

54. Cytokinesis occurs during telophase, separating each daughter nucleus into a separate cell that then begins interphase.

55. Cytokinesis
Fig. 8-9g

56. During cytokinesis, the cytoplasm is divided between two daughter cells.
Microfilaments form a ring around the cell’s equator.
The microfilament ring contracts, pinching in the cell’s “waist.”
The waist completely pinches off, forming two daughter cells
(a)
Microfilaments contract, pinching the cell in two
(b)
Scanning electron micrograph of cytokinesis.
Fig. 8-10

57. Cytokinesis in plant cells is different than in animal cells.
In plants, carbohydrate-filled vesicles bud off the Golgi apparatus and line up along the cell’s equator between the two nuclei.
The vesicles fuse, forming a cell plate.
The carbohydrate in the vesicles become the cell wall between the two daughter cells.

61. Prokaryotic cell cycle

62. The prokaryotic cell cycle consists of a long period of growth, during which the cell duplicates its DNA.
cell division by binary fission
cell growth and DNA replication
(a)
The prokaryotic cell cycle
Fig. 8-3a

63. 1.Binary fission occurs among prokaryotes (cells that do not contain a nucleus).
2.Mitosis occurs among eukaryotes (cells that have a nucleus).
3.Binary fission does not include spindle formation (mitotic apparatus) and sister chromatids in its process making it a faster means of cellular division than mitosis.
4.Binary fission does not have the four distinct cellular phases (from G1 down to the final mitotic phase) that are seen in mitosis.