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Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.

Published byΖήνων Βενιζέλος Modified over 6 years ago

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Presentation on theme: "Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic."— Presentation transcript:

1 Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms  Vladimir Grigoryants, MD, Kevin K. Hannawa, BS, Charles G. Pearce, BA, Indranil Sinha, BA, Karen J. Roelofs, DVM, Gorav Ailawadi, MD, Kristopher B. Deatrick, BA, Derek T. Woodrum, MD, Brenda S. Cho, MS, Peter K. Henke, MD, James C. Stanley, MD, Matthew J. Eagleton, MD, Gilbert R. Upchurch, MD  Journal of Vascular Surgery  Volume 41, Issue 1, Pages (January 2005) DOI: /j.jvs Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Mean aortic diameter increase (%) compared to preperfusion aortic diameter 7 and 14 days after elastase perfusion. *P = .002. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Catalase mRNA expression on 7 and 14 days after elastase perfusion. *P = .02. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Catalase protein change (%) in aortas of tamoxifen-treated rats relative to control rats. *P = .04. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Immunohistochemical staining (×100 magnification) for catalase (arrows) in control (A) and tamoxifen-treated group (B) 14 days after elastase perfusion. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 Gelatin zymography of representative aortic samples 7 days after elastase perfusion. MMP-9 activity is 2.4 times higher in control rats (C) compared to tamoxifen-treated rats (T), P = .01. MMP-2 activity is similar in the two groups, P = .37. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

7 Fig 6 PMNs and macrophage counts in the aortic wall 7 and 14 days after elastase perfusion. *P = .05. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

8 Fig 7 Anti-PMN antibody staining (×100 magnification) showing aortic PMN infiltration (arrows) in control (A) and tamoxifen-treated (B) aortas 7 days after elastase perfusion. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

9 Fig 8 Mean aortic diameter increase (%) 14 days after elastase perfusion in groups with and without catalase inhibitor. *P < .05 in comparison to tamoxifen+AT, control+AT, and control groups. **P < .05 in comparison to tamoxifen and control groups. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

10 Fig 9 Catalase protein change (%) in aortas of tamoxifen+AT–treated rats relative to control+AT–treated rats. *P = .003. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

11 Fig 10 Mean aortic diameter increase (%) 14 days after elastase perfusion without (control) and with catalase supplementation. *P = .01. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

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