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Late Breaking Clinical Trials

Published byἈληκτώ Παπάγος Modified over 6 years ago

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Presentation on theme: "Late Breaking Clinical Trials"— Presentation transcript:

1 Late Breaking Clinical Trials
ISAR-REACT Trial Intracoronary Stenting and Antithrombotic Regimen Rapid Early Action for Coronary Treatment Presented at ACC 2003 Late Breaking Clinical Trials

2 ISAR-REACT Trial 2,159 low-risk patients undergoing elective stenting, excluding patients with: Acute coronary syndrome Acute MI with 14 days ST-segment depression Positive biomarkers Insulin-dependent diabetes Chronic total occlusions EF <=30% Thrombus presence Lesions in bypass grafts Clopidogrel (600 mg loading dose, 2 x 75 mg/d through discharge, 75 mg/d for 4 weeks) Abciximab (n = 1,079) Placebo (n = 1,080) Endpoints: Primary – 30 day death / MI / urgent target vessel revascularization Secondary –30 day bleeding complications ACC 2003, Late Breaking Trials

3 ISAR-REACT Trial: 30 Day Endpoints
Death / MI / Urgent TVR Death Urgent TVR P = 0.82 P = NS P = NS Abciximab Placebo Abciximab Placebo Abciximab Placebo ACC 2003, Late Breaking Trials

4 ISAR-REACT Trial: Bleeding Results
TIMI Major Bleed TIMI Minor Bleed Transfusion P = NS P = NS P < 0.05 Abciximab Placebo Abciximab Placebo Abciximab Placebo ACC 2003, Late Breaking Trials

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