1. Furosemide stimulates macula densa cyclooxygenase-2 expression in rats
Bianca Mann, Andrea Hartner, Boye L. Jensen, Martin Kammerl, Bernhard K. Krämer, Armin Kurtz 
Kidney International 
Volume 59, Issue 1, Pages (January 2001)
DOI: /j x
Copyright © 2001 International Society of Nephrology Terms and Conditions

2. Figure 1
Effects of furosemide (12 mg/kg per day) and hydrochlorothiazide (HCT; 30 mg/kg per day) on urine production (A), hematocrit (B), and body weight gain (C) in rats. Data are means ± SEM of 18 vehicle-infused, 18 furosemide-infused, 6 vehicle-fed, and 6 HCT-fed animals. *P < 0.05 vs. respective control.
Kidney International  , 62-68DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

3. Figure 2
Plasma renin activity (A) and renal renin mRNA abundance (B) in vehicle-treated and in furosemide or hydrochlorothiazide (HCT)-treated infused rats. Data are means ± SEM. *P < 0.05 vs. respective control.
Kidney International  , 62-68DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

4. Figure 3
Cyclooxygenase (COX)-2 mRNA (A) and COX-1 mRNA (B) abundance in the renal cortex from vehicle-treated, furosemide, or HCT-treated rats. Data are means ± SEM. *P < 0.05 vs. respective control.
Kidney International  , 62-68DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

5. Figure 4
Distribution of COX-2 immunoreactivity in rat kidney cortex from a vehicle-infused rat (A) and a rat infused with furosemide (B; magnification ×100). (C) Localization of COX-2 immunoreactivity in the macula densa of a furosemide-infused rat (magnification ×400).
Kidney International  , 62-68DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions

6. Figure 5
COX-2 immunoreactivity in the renal cortex of vehicle, furosemide, or HCT-treated rats. COX-2 immunoreactivity is given as COX-2 index, that is, the percentage cut glomeruli in a section displaying COX-2 immunoreactivity in the juxtaglomerular apparatus. Data are means ± SEM. *P < 0.05 vs. respective control.
Kidney International  , 62-68DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions