1. What does this protein make up or do?
Chapter 11: Chromosome 11
DNA Sequence
Chromosome
4888 bp
Name of Protein 11
Name of Gene
polyalanine
PHOX2B
transcription
Amino acid sequence
mRNA
314 aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
Helps form nerve cells during early development
Condition/Disease
Neuroblastoma

2. Description of Neuroblastoma
Symptoms and characteristics
Neuroblastoma is one of the few human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance. It is a disease exhibiting extreme heterogeneity, and is stratified into three risk categories: low, intermediate, and high risk. Low-risk disease is most common in infants and good outcomes are common with observation only or surgery, whereas high-risk disease is difficult to treat successfully even with the most intensive multi-modal therapies available
Normal Vision
As viewed by a person with glaucoma
Pictures used with permission from URL:

3. Description of Neuroblastoma (cont.)
Who is affected?
Everyone, as it is a cancer, but it is sporadic and unpredictable so far
Outlook or quality of life
It is a severe cancer, so the outlook of life can be compared to that of a breast cancer patient. This means multiple surgeries and types of therapy. These are both expensive and take a very long time to recover from.
Researcher: BB

4. References
NCBI. Genes and Disease: Glaucoma [online] [cited 2004 July 14]. Available at URL:
NCBI. Entrez [online] [cited 2004 July 14]. Available at URL:
National Eye Institute. Glaucoma: What you should know [online] [cited July 14]. Available at URL: