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Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation.

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Presentation on theme: "Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation."— Presentation transcript:

1 Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes.
Cytokines trigger proliferation and block differentiation of perivascular adipocytes. In study arm 2, human preadipocytes were isolated from PVAT around the RCA and differentiated in the presence or absence of inflammatory cytokines [recombinant TNF-α (4 ng/ml) + IL-6 (25 ng/ml) + IFN-γ (20 ng/ml)] until day 9 of differentiation [(A and B) without cytokines and (C and D) with cytokines, oil red O staining at day 9 of differentiation]. (E) Oil red O photometric quantification of lipid accumulation in preadipocytes differentiated with and without cytokines (n = 7). Effects of cytokines on (F) preadipocyte proliferation and gene expression of the differentiation markers (G) PPAR-γ, (H) CEBPA, and (I) FABP4 (n = 3 independent experiments in triplicate). P values derived from Wilcoxon signed-rank test (E) or two-way ANOVA with “time × treatment” interaction (F to I). Alexios S. Antonopoulos et al., Sci Transl Med 2017;9:eaal2658 Published by AAAS

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