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Oral steroids and doxycycline: Two different approaches to treat nasal polyps  Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,

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Presentation on theme: "Oral steroids and doxycycline: Two different approaches to treat nasal polyps  Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,"— Presentation transcript:

1 Oral steroids and doxycycline: Two different approaches to treat nasal polyps 
Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels, Achim Beule, MD, Peter John Wormald, MD, Susanne Mayr, MD, Greet Hens, MD, PhD, Peter Hellings, MD, PhD, Fenna A. Ebbens, MD, PhD, Wytske Fokkens, MD, PhD, Paul Van Cauwenberge, MD, PhD, Claus Bachert, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 5, Pages e4 (May 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Polyp size after treatment with methylprednisolone (solid circles) vs placebo (solid triangles) or doxycycline (solid squares) vs placebo. The mean changes from baseline were significantly different between the methylprednisolone and placebo groups (∗P < .05) and between the doxycycline and placebo groups (§P < .05). NPIF values were affected by methylprednisolone (solid circles) compared with placebo (solid triangles) and doxycycline (solid squares) compared with placebo. Area under the curve (AUC) values were calculated for methylprednisolone, doxycycline, and placebo, including negative peaks. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Nasal symptoms after treatment with methylprednisolone (solid circles) vs placebo (solid triangles) or doxycycline (solid squares) vs placebo. The mean changes from baseline were significantly different between the methylprednisolone and placebo groups (∗P < .05) and between the doxycycline and placebo groups (§P < .05). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Serum inflammatory parameters, blood eosinophilia, serum soluble IL-5Rα, and serum ECP levels after treatment with methylprednisolone (solid circles) vs placebo (solid triangles) or doxycycline (solid squares) vs placebo. The mean changes from baseline were significantly different between the methylprednisolone and placebo groups (∗P < .05) and between the doxycycline and placebo groups (§P < .05). MPO, Myeloperoxidase. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Inflammatory markers in nasal secretions after treatment with methylprednisolone (solid circles) vs placebo (solid triangles) or doxycycline (solid squares) vs placebo. The mean changes from baseline were significantly different between the methylprednisolone and placebo groups (∗P < .05) and between the doxycycline and placebo groups (§P < .05). sol, Soluble. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Study design. At visit 1, randomized allocation to 1 of the 3 treatment groups took place. Follow-up visits were scheduled at 1, 2, 4, 8, and 12 weeks after randomization. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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