1. Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.25
Figure 3 Examples of multistep algorithms for testing stool samples for rapid diagnosis of CDI
Figure 3 | Examples of multistep algorithms for testing stool samples for rapid diagnosis of CDI. a | Diagnostic pathways using GDH as first-line test: GDH + toxin EIA (1); GDH + cytotoxin assay (2); and GDH + toxin EIA + PCR (3). b | Diagnostic pathways using NAAT as first-line test (1): NAAT + toxin EIA (2); NAAT + cytotoxin assay. CDI, Clostridium difficile infection; EIA, enzyme immunoassay; GDH, glutamate dehydrogenase; NAAT, nucleic acid amplification test. *Cytotoxin assay method takes longer than toxin EIA, but has greater sensitivity. ‡A negative toxin test result could be false-negative and so management of the patient should always include a clinical assessment. §NAAT or PCR does not distinguish between CDI and colonization.
Martin, J. S. H. et al. (2016) Clostridium difficile infection: epidemiology, diagnosis and understanding transmission
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