1. Outline of the problem and experimental approach.
Outline of the problem and experimental approach. Factors contributing to childhood undernutrition are marked with red arrows. Enteric infection can lead to gut dysfunction that makes reinfection more likely, a condition known as environmental enteropathy. Undernourished children are stunted, which is defined by a HAZ score < −2. The red dots on the HAZ scale correspond to scores of children at 1 y of age whose data were analyzed. Genome-wide maps of H3K4me3 were obtained using PBMCs from children at 18 wk and 52 wk of age, as well as their mothers.
Robin Uchiyama et al. PNAS 2018;115:48:E11264-E11273
©2018 by National Academy of Sciences