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Published byMilena Stefany Gil Quintanilha Modified over 5 years ago
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Next generation sequencing in women affected by nonsyndromic premature ovarian failure displays new potential causative genes and mutations Dora Janeth Fonseca, Ph.D., Liliana Catherine Patiño, M.Sc., Yohjana Carolina Suárez, M.Sc., Asid de Jesús Rodríguez, M.Sc., Heidi Eliana Mateus, M.D., M.Sc., Karen Marcela Jiménez, M.Sc., Oscar Ortega-Recalde, M.D., M.Sc., Ivonne Díaz-Yamal, M.D., Paul Laissue, M.D., Ph.D. Fertility and Sterility Volume 104, Issue 1, Pages e2 (July 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Chromatograms of POF patients presenting ADAMTS19, BMPR2, and LHCGR mutations. (A) POF7 patient: ADAMTS19-c.2828C>T mutation. (B) POF19 patient: BMPR2 c.2960C>T and LHCGR-c.296A>G. (C) POF23 patient: c.526T>C. WT = wild type sequences. Arrows indicate positions of heterozygous mutations. Fertility and Sterility , e2DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Supplemental Figure 1 Pedigree of POF19 family. Completely dashed symbols refer to the affected individual (POF19) carrying both BMPR2 and LHCGR mutations. Half dashed symbols refer to heterozygous carriers (BMPR2 or LHCGR mutations). Fertility and Sterility , e2DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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