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BRAF V600E Mutation Is not Always Present as Expected

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Presentation on theme: "BRAF V600E Mutation Is not Always Present as Expected"— Presentation transcript:

1 BRAF V600E Mutation Is not Always Present as Expected
BRAF V600E Mutation Is not Always Present as Expected! A Case Report of Lung and Thyroid Carcinomas  Nicolas Piton, MD, MPhil, Mathieu Salaün, MD, PhD, Florian Guisier, MD, MRes, Florent Marguet, MD, MRes, Emmanuel K. Touré, MD, Pierre Gémival, MD, Luc Thiberville, MD, PhD, Jean-Christophe Sabourin, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 5, Pages (May 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Computed tomography scans: mediastinal window (I), parenchymal window (II), initially (day 0) (A), and after treatment by carboplatin-taxol (day 170) (B). Mediastinal lymph nodes have increased in size (I), and an ill-defined lesion has appeared in the right lower lobe with right pleural effusion (II). (C) After second-line treatment with dabrafenib (day 483), mediastinal lymph nodes and the right lung lesion have dramatically regressed, with only a mild right pleural effusion remaining. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Photomicrographs of formalin-fixed paraffin-embedded tissue section of a cervical lymph node after staining by hematoxylin and eosin and by Safran (A) and immunostaining for BRAF V600E (B). This lymph node is infiltrated by both a papillary thyroid carcinoma for which the results of staining for BRAF V600E were negative (white star) and a BRAF V600E–positive adenocarcinoma (black star and arrow). Bar scales: 50 μm for (AI), (BI), (AIII), and (BIII) and 200 μm for (AII) and (BII). Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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