1. Writing Cochrane Protocol Cochrane Thailand Workshop 2017
Chumnan Kietpeerakool
November 2017
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

2. Cochrane Protocol & Review: components of a protocol development
Contact Managing Editor first to ask for the availability of the title of interest before developing the protocol
Have to publish review protocol before developing a full review
Title Registration Form (TRF)
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

3. Cochrane Protocol & Review: components of a protocol development
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

4. Cochrane Protocol & Review: components of a protocol development
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

5. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

6. Software programs to be used for developing the protocol and review
RevMan
Covidence
GRADEpro GDT
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

7. Software programs to be used for developing the protocol and review
RevMan
Review Manager 5 (RevMan 5) is the software used for preparing and maintaining Cochrane Reviews.
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

8. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

9. Covidence: What can you do in Covidence?
Import citations
Screen titles and abstracts
Upload references
Screen full text
Create forms
Risk of Bias
Do Data extraction
Export
“When we discovered Covidence it was like an angel had come down from the sky!”
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

10. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

11. Software programs to be used for developing the protocol and review
GRADEpro GDT: an easy to use, all‐in‐one web solution to summarise and present information for healthcare decision making.
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

12. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

13. Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

14. Protocol Development: Background and objective
Addressing the rationale for the review, and explaining the important of the questions being asked
Should be concise (generally around one page when printed) and be understandable to the users of the intervention under investigation
Citing all sources of information
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

15. Protocol Development: I
Components of background
Description of the condition
Description of the intervention
How the intervention might work
Why it is important to do this review
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

16. Protocol Development: I
Description of the condition
How and where the condition occurs, affected group, diagnosis, symptoms and consequences
A brief description of the condition being addressed and its significance
Information about the biology, diagnosis, prognosis and public health impact (including prevalence or incidence)
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

17. Protocol Development: I
Description of the intervention
Providing a brief description of the intervention, including for whom it intended, its context in usual practice, comparison interventions, the treatment regimen or intervention components, and any known adverse effects
For drugs, basic information on clinical pharmacology should be presented including dose range, metabolism, selective effects, half-life, duration and any known interactions with other drugs
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

18. Protocol Development: I
How the intervention might work
Describe the theoretical reasoning why the interventions under review may have an impact on potential recipients
Refer to a body of empirical evidence such as similar interventions having an impact or identical interventions having an impact on other populations
Refer to a body of literature that justifies the possibility of effectiveness
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

19. Protocol Development: I
Why it is important to do this review
Is there conflicting evidence?
Have new RCTs recently been published?
Is there any previous systematic review of this subject?
Outline why this topic area is currently important
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

20. Protocol Development: I
Objectives
Beginning with a precise statement of the primary objective of the review, ideally in a single sentence
Might be followed by a series of specific objectives relating to different participant groups, different comparisons of interventions or different outcome measures
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

21. Protocol Development: I
The format should be as follows:
To assess the effects of [intervention or comparison] for [health problem] for/in [types of people, disease or problem and setting if specified] OR
To evaluate the effectiveness and safety of [intervention] for [disease] in [patients]
To compare the effectiveness and safety of [intervention] with that of [state the comparison intervention] for [disease] in [patients]
To evaluate the benefit and harms of different treatment modalities (offered in current practice?) for the management of [disease] in [patients]
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

22. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

23. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

24. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

25. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

26. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

27. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

28. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence

29. Protocol Development: I
Our vision is that healthcare decision-making throughout the world will be informed by high quality, timely research evidence