1. Modulation of microvascular permeability in the preovulatory rat ovary by an ovulatory gonadotropin stimulus 
Kenrokuro Mitsube, M.D., Ph.D., Mats Brännström, M.D., Ph.D., Börje Haraldsson, M.D., Ph.D. 
Fertility and Sterility 
Volume 99, Issue 3, Pages (March 2013)
DOI: /j.fertnstert
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
The figure shows the distribution of FITC-Ficoll in plasma and in ovarian interstitial fluid (A) and the concentration ratio of Ficoll in normal unstimulated ovaries (B). In panel A, the FITC-Ficoll distribution from a representative experiment is shown as the relative concentration of the peak concentration for plasma and ovarian interstitial fluid, respectively. Passage of larger molecules from the blood compartment into the ovary was restricted, since the ovarian interstitial fluid curve is shifted to the left. In panel B, the concentration ratio of Ficoll in normal unstimulated ovaries is plotted against molecular size expressed as the Stokes-Einstein radius (Å). For each of the 16 animals, a matched pair of ovarian interstitial fluid and plasma was taken and analyzed using HPLC. Based on the calibration procedure, more than 200 data-pairs were selected for the Ficoll molecular size range between 12 Å and 74 Å. In the graph, every fifth value is plotted (mean ± SEM). Also shown is the theoretical/calculated curve obtained from the two-pore model (dotted curve).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
An illustration of the ovarian microcirculation at ovulation that basically treats the capillary as having two components: (a) an arterial part and (v) a venular end of the capillary. For the sake of simplicity, the large pores are mainly present in the venular end of the capillary (17). At the arterial part of the capillary, there is a simple Starling equilibrium between hydrostatic and colloid osmotic pressures giving rise to a net fluid filtration (Jvs) of 39 μL/minute. At the venular end, there is reabsorption across the small pores and filtration across the large pores with almost the same rates (10 μL/minute). Thus, there is a volume circulation between small and large pores at the venular end causing a net transport of macromolecules. This volume circulation accounts for 24% of the net filtration under the conditions in the graph.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

4. Figure 3
The concentration ratios for Ficoll are plotted against molecular size expressed as the Stokes-Einstein radius (Å) for unstimulated control ovaries and ovaries 30 minutes and 2, 4, and 8 hours after hCG stimulation. Note that stimulation with hCG shifts the curves to the left particularly for the larger solutes. Maximum is reached between 2 and 4 hours.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

5. Figure 4
The figure shows (A) the estimated large pore fraction of the total hydraulic conductance (LpS%), (B) the changes in small pore radius (rS), and (C) the changes in large pore radius (rL). The results are presented as means ± SEM. In panel A, the changes in the estimated large pore fraction of the total hydraulic conductance (LpS%) and in the ovarian microvasculature before (0 hours) and after hCG are shown. Treatment with hCG caused a significant three-fold increase of LpS% at the 2- and 4-hour time points (∗P<.05). In panel B, the apparent small pore radius (rS) in the ovarian microvasculature is shown during control (0 hours) and at different times after hCG. Stimulation with hCG significantly (∗∗P<.01) increased rS at the 2-hour time point. In panel C, the apparent large pore radius (rL) in the ovarian microvasculature before (0 hours) and after hCG is shown. Treatment with hCG significantly (∗∗P<.01) increased rL at the 2-hour time point.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions