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Residual Risk After Statin Therapy:

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Presentation on theme: "Residual Risk After Statin Therapy:"— Presentation transcript:

1 Residual Risk After Statin Therapy:

2

3 Residual CVD Risk Despite OMT

4 TG Independently Predicts CVD: Confusion About Adjusting for Non-HDL-C

5 Lipoprotein Lipase Clears Triglycerides From the Circulation

6 Recent Genetic Studies Do Support Causality of TGRLP in CV risk

7 Lipoprotein Lipase: A Central Hub in Metabolism of TGRLP

8 Overview of TG Metabolism

9 Elevated TG Concentrations in Non-Statin-Treated Patients Associated With MACE and MI

10 Increasing TG Levels Increase Risk of Pancreatitis

11 Assessing TGRLP Levels: Which Method Is Best?

12 No Fasting Required: Practical Algorithm for Screening and Managing Elevated TG

13 Treatment Approach for TG ≥ 500 mg/dL to Reduce Risk of Pancreatitis

14 Treatment Approach for TG 200 to 500 mg/dL

15 CV Outcomes Trials in Patients With Hypertriglyceridemia

16 Risk Difference vs Placebo of HTG Subgroups Primary and Secondary CVD Prevention Trials

17 Why Have CVOTs of TG-Lowering Drugs Failed to Reach Primary Endpoints?

18 Fish Oil Supplements vs Prescription Omega-3 FAs

19 What Is on the Horizon?

20 Conclusion

21


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