Presentation is loading. Please wait.

Presentation is loading. Please wait.

Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

Published byHarriet Baker Modified over 6 years ago

Similar presentations

Presentation on theme: "Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)"— Presentation transcript:

1

2

3

4

5 Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)

6

7 ATP used to Initiate β-oxidation

8

9

10 Page 746

11 NADPH

12

13

14

15 Cascade for Biosynthesis of Eicosanoids
2

16 Biosynthesis of Eicosanoids
Mammals (unsaturation anabolism) C9 Plants (unsaturation anabolism) Arachadonic Acid (ω-6) Cleaved from phospholipids via a phospholipase Cyclooxygenases Prostaglandins (thromboxanes) Leukotrienes 3

17 COX catalyzed reaction
4

18 COX Inhibitors 5

19 COX Inhibitors 5

20 Aspirin – Mode of Action
6

Download ppt "Familial Hypercholesterolemia – Genetic disease from a mutation of the LDL receptor (doesn’t remove LDL from circulation)"

Similar presentations

Chapter 34 Neuroinflammation

Chapter 34 Neuroinflammation
MEMBRANE LIPIDS I and II:

MEMBRANE LIPIDS I and II:
Awatif B. Al-Backer. Inflammation Definition: It is a protective response against injury which can be chemicals, mechanical, infectious, or immunological.

Awatif B. Al-Backer. Inflammation Definition: It is a protective response against injury which can be chemicals, mechanical, infectious, or immunological.
Eicosanoid Synthesis Molecular Biochemistry II

Eicosanoid Synthesis Molecular Biochemistry II
SYNTHESIS OF AN ARACHIDONIC ACID ANALOG. Arachidonic Acid Cascade The biological actions of arachidonic acid have essentially been attributed to the conversion.

SYNTHESIS OF AN ARACHIDONIC ACID ANALOG. Arachidonic Acid Cascade The biological actions of arachidonic acid have essentially been attributed to the conversion.
Prostaglandins and Related Compounds 1Dr. Nikhat Siddiqi.

Prostaglandins and Related Compounds 1Dr. Nikhat Siddiqi.
BIOC 460 DR. TISCHLER LECTURE 34 SYNTHESIS & PROCESSING OF FATS.

BIOC 460 DR. TISCHLER LECTURE 34 SYNTHESIS & PROCESSING OF FATS.
Hormones & Chemical Signaling. Lecture Outline Communication Basics –Communication Overview –Communication Methods –Signal pathways Types Regulation (modulation)

Hormones & Chemical Signaling. Lecture Outline Communication Basics –Communication Overview –Communication Methods –Signal pathways Types Regulation (modulation)
Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids.

Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids.
Lipid Metabolism 3: Cholesterol biosynthesis, lipoprotein metabolism, steroid and eicosanoid synthesis Bioc 460 Spring 2008 - Lecture 37 (Miesfeld) Steroids.

Lipid Metabolism 3: Cholesterol biosynthesis, lipoprotein metabolism, steroid and eicosanoid synthesis Bioc 460 Spring Lecture 37 (Miesfeld) Steroids.
Metabolic Pathways Most of the ATP that is generated in the body is produced through the process of oxidative phosphorylation. This process is dependent.

Metabolic Pathways Most of the ATP that is generated in the body is produced through the process of oxidative phosphorylation. This process is dependent.
Eicosanoid Metabolism Medical Biochemistry Lecture #50.

Eicosanoid Metabolism Medical Biochemistry Lecture #50.
LIPID ANABOLISM. fig 21-1 acetyl-CoA carboxylase.

LIPID ANABOLISM. fig 21-1 acetyl-CoA carboxylase.
BIOCHEMISTRY LECTURES. Space-filling models of (A) palmitate (C16, saturated) and (B) oleate (C18, unsaturated). The cis double bond in oleate produces.

BIOCHEMISTRY LECTURES. Space-filling models of (A) palmitate (C16, saturated) and (B) oleate (C18, unsaturated). The cis double bond in oleate produces.
Carbohydrates of Physiologic Significance CARBOHYDRATES ARE ALDEHYDE OR KETONE DERIVATIVES OF POLYHYDRIC ALCOHOLS (1) Monosaccharides are those carbohydrates.

Carbohydrates of Physiologic Significance CARBOHYDRATES ARE ALDEHYDE OR KETONE DERIVATIVES OF POLYHYDRIC ALCOHOLS (1) Monosaccharides are those carbohydrates.
Steroid Hormones Cholesterol Starting material.

Steroid Hormones Cholesterol Starting material.
1 Esterification Alcohols and carboxylic acids react to form esters in a reaction known as esterification. The reverse reaction is hydrolysis. Hydrolysis.

1 Esterification Alcohols and carboxylic acids react to form esters in a reaction known as esterification. The reverse reaction is hydrolysis. Hydrolysis.
Lipids Function of Lipids

Lipids Function of Lipids
Energy economy of the cells

Energy economy of the cells
Metabolism of Unsaturated Fatty Acids & Eicosanoids

Metabolism of Unsaturated Fatty Acids & Eicosanoids

Similar presentations

Ads by Google