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Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease  Andrew E. Hendifar,

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Presentation on theme: "Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease  Andrew E. Hendifar,"— Presentation transcript:

1 Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease  Andrew E. Hendifar, MD, MPH, Alberto M. Marchevsky, MD, Richard Tuli, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 3, Pages (March 2017) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Morphologic criteria for distinguishing lung NETs. Tumors with neuroendocrine morphology are divided into the four subtypes primarily according to the number of mitoses and presence or absence of necrosis. NET, neuroendocrine tumor; NE, neuroendocrine. Adapted from Travis8 with permission. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Ki-67 labeling index distribution in the four subtypes of lung neuroendocrine tumors: typical carcinoid (A), atypical carcinoid (B), large cell neuroendocrine carcinoma (C), and SCLC (D). Reprinted from Pelosi et al.30 with permission. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Diagnostic evaluation/work-up recommendations according to the European Neuroendocrine Tumor Society guidelines for typical carcinoids (TCs) and atypical carcinoids (ACs). aAccurate echocardiographic evaluation should always be carried out before surgical procedures and at both diagnosis and follow-up to evaluate the presence and evolution of carcinoid heart disease. NET, neuroendocrine tumor; MEN-1, multiple endocrine neoplasia type 1; PTH, parathyroid hormone; CT, computed tomography; 5-HIAA, 5-hydroxyindoleacetic acid; ACTH, adrenocorticotropic hormone; GHRH, growth hormone–releasing hormone; IGF-1, insulin growth factor 1; MRI, magnetic resonance imaging; EBUS, endobronchial ultrasonography; PET, positron emission tomography; FDG-PET, fludeoxyglucose F 18 positron emission tomography. Reprinted from Caplin et al.15 with permission. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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