1. Single vs Dual HER2 Blockade for Metastatic HER2-Positive Breast Cancer

2. Program Goals

3. Changes to the Standard of Care for HER2-Positive Disease

4. CLEOPATRA Trial Results

5. CLEOPATRA Updated Overall Survival Analysis

6. Administering Dual HER2 Blockade

7. Are All Patients Candidates for Dual HER2 Blockade?

8. Pertuzumab /Trastuzumab /Docetaxel Safety Profile

9. Approaches in Different Scenarios

10. Neoadjuvant Therapy

11. Surgery in a Patient With Stage IV Breast Cancer

12. Investigational Trials

13. Abbreviations

14. References

15. References (cont)

16. References (cont)