1. New class of anti-inflammatory agents for colonic epithelial cells
Dan Gordon 
Gastroenterology 
Volume 117, Issue 5, (November 1999)
DOI: /S (99)
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2. NF-κB transduces signals from many types of proinflammatory agents, leading to production of cytokines that promote the inflammatory response. Glucocorticoids prevent the first step of NF-κB activation, dissociation of an inhibitor known as IKB and translocation of activated NF-κB to the nucleus. The nuclear receptor known as PPAR-γ, when activated, prevents transcriptional activation of proinflammatory genes by NF-κB. Drugs that can activate PPAR-γ, including thiazolidinedione antidiabetic drugs and certain prostaglandins, thus can exert anti-inflammatory effects. This system appears to be very active in colonic epithelial cells and may serve as an alternate target for treatment of inflammatory bowel disease.
Gastroenterology  , DOI: ( /S (99) )
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