1. Ubiquitin and immune system modulationCells of both the innate and adaptive arms of the immune system are crucial for immune reactivity and self‐tolerance.
Ubiquitin and immune system modulationCells of both the innate and adaptive arms of the immune system are crucial for immune reactivity and self‐tolerance. Defects in the expression of E3 ligases or DUBs can lead to deregulation of these processes which can resulting in autoimmunity or autoinflammation. Autoimmune disorders are characterised by disturbed function of mTEC and DCs (impairment in their presentation of self‐peptides to T cells; highlighted in red) or by perturbed peripheral tolerance, which will lead to the development of self‐reactive T and/or B cells (highlighted in red), production of autoantibodies and subsequent tissue destruction. During autoinflammation, the innate immune cells are hyperactive (highlighted in red) and release pro‐inflammatory cytokines, including IL‐1β and TNF, which will result in the development of auto‐reactive inflammation.
Julia Zinngrebe et al. EMBO Rep. 2014;15:28-45
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