1. The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid 
X. Tong, N. Ratnaraj, P.N. Patsalos 
Seizure - European Journal of Epilepsy 
Volume 16, Issue 1, Pages (January 2007)
DOI: /j.seizure
Copyright © 2006 British Epilepsy Association Terms and Conditions

2. Figure 1
Vigabatrin concentration vs. time profiles in serum after 250mg/kg (♦), 500mg/kg (■) and 1000mg/kg (▴) vigabatrin administration. Data are mean±S.E.M. of 6–7 animals.
Seizure - European Journal of Epilepsy  , 43-49DOI: ( /j.seizure )
Copyright © 2006 British Epilepsy Association Terms and Conditions

3. Figure 2
Vigabatrin free/total concentration ratio at different vigabatrin concentrations (13–1378μmol/l) over time.
Seizure - European Journal of Epilepsy  , 43-49DOI: ( /j.seizure )
Copyright © 2006 British Epilepsy Association Terms and Conditions

4. Figure 3
Vigabatrin concentration vs. time profiles in CSF after 250mg/kg (▴), 500mg/kg (♦) and 1000mg/kg (■) vigabatrin administration. Data are mean±S.E.M. of 6–7 animals.
Seizure - European Journal of Epilepsy  , 43-49DOI: ( /j.seizure )
Copyright © 2006 British Epilepsy Association Terms and Conditions

5. Figure 4
Relationship between vigabatrin concentrations in serum and CSF. Data are those from 500mg/kg vigabatrin administration. The equation for linear regression is y= ; r2=
Seizure - European Journal of Epilepsy  , 43-49DOI: ( /j.seizure )
Copyright © 2006 British Epilepsy Association Terms and Conditions

6. Figure 5
CSF/serum vigabatrin concentration ratios vs. time after 250mg/kg (■), 500 (♦) and 1000 (▴) mg/kg vigabatrin administration. Data are mean±S.E.M. of 6–7 animals.
Seizure - European Journal of Epilepsy  , 43-49DOI: ( /j.seizure )
Copyright © 2006 British Epilepsy Association Terms and Conditions