1. Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2015.166
Figure 3 Comparison of human and mouse pancreatic neuroplasticity in chronic pancreatitis and pancreatic cancer
Figure 3 | Comparison of human and mouse pancreatic neuroplasticity in chronic pancreatitis and pancreatic cancer. The characteristic features of human neuroplasticity and neuropathy in these two diseases are neural hypertrophy, increased neural density, neural invasion, pancreatic neuritis, Schwann cell accumulation around PanIN lesions, and neural remodelling.14,49,70 By contrast, the mouse pancreas does not contain any of the large nerve trunks that are readily encountered in human chronic pancreatitis or pancreatic cancer, exhibits no neuritis, and also no true neural invasion. All studies that asserted the detection of neural invasion in pancreatic cancer in mice in fact demonstrate epineural association of cancer cells. However, as in human pancreatic neuropathy, Schwann cells of peripheral nerves are rapidly detectable around PanIN lesions in genetically engineered mouse models of pancreatic cancer70 (listed). No studies have demonstrated human-like neural remodelling with suppressed sympathetic pancreatic innervation in any of the mouse models of chronic pancreatitis or pancreatic cancer. Abbreviations: PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma; TNBS, trinitrobenzene sulphonic acid.
Demir, I. E. et al. (2015) Neural plasticity in pancreatitis and pancreatic cancer
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