1. p53 and Apoptosis: It's Not Just in the Nucleus Anymore
James J. Manfredi 
Molecular Cell 
Volume 11, Issue 3, Pages (March 2003)
DOI: /S (03)
Copyright © 2003 Cell Press Terms and Conditions

2. Figure 1
p53 Mediates Apoptosis by Direct Effects in Both the Nucleus and the Mitochondria
A well-characterized pathway involves p53-mediated effects in the nucleus (blue) on gene expression leading to a transcriptional-dependent induction of apoptosis. A variety of relevant target genes have been identified and are listed here. Recent studies from Mihara et al. and Dumont et al. support a second, transcriptionally independent pathway involving localization of p53 to the mitochondria (yellow), followed by binding and inhibition of bcl-xL and/or bcl-2.
Molecular Cell  , DOI: ( /S (03) )
Copyright © 2003 Cell Press Terms and Conditions