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Neurotransmitter Recovery and Degradation

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Presentation on theme: "Neurotransmitter Recovery and Degradation"— Presentation transcript:

1 Neurotransmitter Recovery and Degradation
Active re-uptake is very important in the CNS

2 Principles of Synaptic Integration
Integration of EPSPs Contribution of dendritic properties: the length constant Inhibition Modulation

3 Studying Neurotransmitter Systems
Criteria for Neurotransmitter Status Molecule must be synthesized and stored in presynaptic neuron Molecule must be released by the presynaptic terminal upon stimulation Molecule must elicit response that mimics that caused by release from the presynaptic neuron

4 Molecule must be synthesized and stored in presynaptic neuron
Immunocytochemistry In Situ Hybridization Autoradiography

5 Molecule must be released by the presynaptic terminal upon stimulation
Chemistry: Stimulate until you release enough transmitter to complete a chemical analysis Physiology: Use a bioassay

6 Ionophoresis & "puffing"
Molecule must elicit response that mimics that caused by synaptic release Ionophoresis & "puffing"

7 Studying Receptors Ligand binding methods Molecular analysis

8 Neurotransmitter Chemistry
Chemical categories Cholinergic Catecholaminergic Serotonergic Amino Acidergic Peptidergic

9 Transmitter Gated Channels
AChR (we've seen it) Amino acid-gated Glutamate Gaba Glycine


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