1. Figure 1 Schematic overview of the LGI1 protein in the synapse
Figure 1 | Schematic overview of the LGI1 protein in the synapse. a | Leucine-rich glioma-inactivated 1 (LGI1) dimers bind to presynaptic ADAM23 (a disintegrin and metalloproteinase 23) and postsynaptic ADAM22. This structure regulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and voltage-gated potassium channel (VGKC) currents. b | Patients' antibodies bind to LGI1 and are presumed to alter neuronal excitability. PSD95, disks large homologue 4.
van Sonderen, A. et al. (2017) The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis
Nat. Rev. Neurol. doi: /nrneurol