1. Synaptic Transmission

2. Electrical & Chemical Synapses

3. Events Involved in Transmission at a Chemical Synapse

4. Local Recycling of Synaptic Vesicles in Presynaptic Terminals

5. Molecular Mechanisms of Neurotransmitter Release

6. Molecular Mechanisms of Neurotransmitter Release

8. Diseases that Affect the Presynaptic Terminal
Several congenital forms result in
fewer or smaller vesicles
= less transmitter
Lambert-Eaton
myasthenic syndrome
= Ab mediated

9. Toxins That Affect Transmitter Release
Toxins cleave SNAREs
Tetanus affects inhibitory
interneurons =
hyperexcitation of muscles
Botulism paralyzes peripheral
muscles = do not contract

10. Toxins That Affect Transmitter Release
Black widow venom =
exocytosis w/o calcium
Binds to CL1 and neurexin,
neurexin binds to synaptotagmin

11. Diseases Caused by Altered Ion Channels
FHM = familial hemiplegic migraine
EA2 = episodic ataxia
CSNB = congenital stationary
night blindness