1. Figure 2 Grey matter atrophy in FTD
Figure 2 | Grey matter atrophy in FTD. Characteristic patterns of grey matter atrophy (highlighted in red) in different clinical and genetic subtypes of frontotemporal dementia (FTD). Patients with behavioural variant FTD (bvFTD) exhibit prominent frontal, insular and anterior cingulate atrophy. Typical temporal atrophy in semantic variant primary progressive aphasia (svPPA) is asymmetrical (most often left-sided). Patients with nonfluent variant primary progressive aphasia (nfvPPA) exhibit left frontal and insular atrophy. In patients with underlying RNA-binding protein FUS (FUS) pathology, nucleus caudatus atrophy is pronounced. Patients with GRN mutations often exhibit asymmetrical frontotemporoparietal atrophy. Patients with a C9orf72 repeat expansion present mostly with a generalized symmetrical atrophy. Patients with MAPT mutations exhibit marked symmetrical temporal atrophy.
Meeter, L. H. et al. (2017) Imaging and fluid biomarkers in frontotemporal dementia
Nat. Rev. Neurol. doi: /nrneurol