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Published byClinton Mark Johns Modified over 6 years ago
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Prevention and Management of Venous Thromboembolic Events in Patients With Multiple Myeloma
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Anticoagulation Regimen Use unfractionated heparin or LMWH at a prophylactic dose for as long as the patient is on therapy
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Patient With Renal Failure Use full-dose warfarin
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Patient With a History of VTE If > 1 VTE evaluate for a possible thrombophilia; in more difficult cases seek a multidisciplinary consult
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Bortezomib-based (IMiD-less) Regimens No need for prophylaxis unless there are additional risk factors
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Relapse Setting Prophylaxis for Patients on Pomalidomide-based Therapy
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IMiD-only Regimens No prophylaxis or use low-dose aspirin
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Patient on IMiD-based Regimen Who Develops a DVT or PE Continue or stop therapy while increasing level of anticoagulation?
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Patient Who Develops a Catheter-related Thrombosis Interrupt therapy while the patient is appropriately managed, then resume therapy
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Patients on IMiDs The risk for thrombosis is greatest during the first few months of therapy
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Patients on IMiDs Need for routine screening in the absence of symptoms
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