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Gastric wall tension determines perception of gastric distention

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1 Gastric wall tension determines perception of gastric distention
Eleonora Distrutti, Fernando Azpiroz, Alfredo Soldevilla, Juan–R. Malagelada  Gastroenterology  Volume 116, Issue 5, Pages (May 1999) DOI: /S (99) Copyright © 1999 American Gastroenterological Association Terms and Conditions

2 Fig. 1 The gastric tensostat is a computerized air pump that applies a constant tension level on the gastric wall. Based on intragastric pressure and volume, the system calculates wall tension and drives the pump to maintain the preselected tension level. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Example of gastric distention with the tensostat. Steps of operation: (1) based on the pressure and volume in the pump, the system corrects for air compressibility; (2) based on corrected intragastric volume and transmural pressure, the system calculates wall tension; and (3) operates the pump to maintain tension within ±1 g of the preselected level. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Effect of shape on wall tension: theoretical validation. Ellipsoidal deformation produces a relatively small decrease in wall tension compared with the sphere. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

5 Fig. 4 Gastric distentions with the barostat. At the same pressure levels, intragastric volume, gastric wall tension, and perception were larger when the stomach was relaxed by glucagon (▴) than during IV saline (□). *P < 0.05 vs. saline. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

6 Fig. 5 Gastric distentions with the tensostat. The same tension levels produced significantly larger intragastric volumes when the stomach was relaxed by glucagon (▴); nevertheless, perception remained similar than during IV saline (□). *P <0.05 vs. saline. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions


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