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Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome Elisabeth Lerchbaum, M.D., Verena Schwetz, M.D., Albrecht Giuliani, M.D., Thomas R. Pieber, M.D., Barbara Obermayer-Pietsch, M.D. Fertility and Sterility Volume 98, Issue 5, Pages e1 (November 2012) DOI: /j.fertnstert Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 (A) Odds ratio with 95% confidence interval (CI) for insulin resistance according to dehydroepiandrosterone sulfate/free testosterone (DHEAS/FT) levels in women with polycystic ovary syndrome (PCOS) (n = 622). The binary logistic regression analyses used insulin resistance as the dependent variable and age, body mass index, waist-to-hip ratio, and DHEAS/FT ratio as independent variables. P=.027 for quartile 4 versus quartile 1 (reference). (B) Odds ratio with 95% CI for insulin resistance according to androgen groups in women with PCOS. The binary logistic regression analyses used insulin resistance as the dependent variable and age, body mass index, waist-to-hip ratio, and androgen groups as independent variables. P<.001 for FT elevated versus DHEAS and FT normal (reference). DHEAS and FT normal: n = 360; DHEAS elevated: n = 110; FT elevated: n = 98; DHEAS and FT elevated: n = 54. (C) Odds ratio with 95% CI for impaired glucose tolerance according to androgen groups in women with PCOS. The binary logistic regression analyses used impaired glucose tolerance as the dependent variable and age, body mass index, waist-to-hip ratio, and androgen groups as independent variables. P=.033 for FT elevated versus DHEAS and FT normal (reference). DHEAS and FT normal: n = 360; DHEAS elevated: n = 110; FT elevated: n = 98; DHEAS and FT elevated: n = 54. Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions
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