1. Microvascular responses to sepsis: clinical significance
Philippe R. Bauer 
Pathophysiology 
Volume 8, Issue 3, Pages (June 2002)
DOI: /S (02)00007-X

2. Fig. 1
Upon inflammatory stimuli (endotoxin, cytokines), endothelial cells induce vasodilation, become a procoagulant surface, upregulate adhesion molecules expression and produce inflammatory components. The consequences include hypotension, vascular thrombosis, neutrophil activation and ischemia-reperfusion injury that may lead to endothelial damage and ultimately apoptosis. (TLR, Toll-like receptor; NF-κB, nuclear factor kappa B; NO, nitric oxide; PAI-1, plasminogen activator inhibitor-1; P-sel, P-selectin; E-sel, E-selectin; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1; CRP, C-reactive protein).
Pathophysiology 2002 8, DOI: ( /S (02)00007-X)