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Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich  Immunity 

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Presentation on theme: "Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich  Immunity "— Presentation transcript:

1 Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer 
Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich  Immunity  Volume 44, Issue 6, Pages (June 2016) DOI: /j.immuni Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Selective Recognition of the Tumor-Associated Hypoglycosylated Forms Tn-STn on MUC-1 by T Cells Engineered to Express the Chimeric Antigen Receptor 5E5 In the absence of the molecular chaperone COSMC (required for stability of the C1GalT1 glycosyltransferase), exposure of the Tn-STn glycoepitope on MUC-1 is favored, leading to selective recognition of tumor cells by 5E5 CAR-T cells. In contrast, sustained expression of COSMC inhibits exposure of these hypoglycosylated epitopes, preventing cytotoxicity induced by engineered 5E5 CAR-T cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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