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UKPDS 35: Impact of Increasing A1c on Cardiovascular Disease in T2DM

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Presentation on theme: "UKPDS 35: Impact of Increasing A1c on Cardiovascular Disease in T2DM"— Presentation transcript:

1 Cardiometabolic Risk in Type 2 Diabetes: What Can the PPAR-g Agonists Teach Us?

2 UKPDS 35: Impact of Increasing A1c on Cardiovascular Disease in T2DM

3 Insulin Resistance Is Associated With or Directly Responsible for Factors Causing Atherothrombosis

4 UKPDS 35: Effect of A1c on MI and Microvascular Events

5 UKPDS 80: 10-Year Follow-up Study of Intensive Glycemic Control in T2DM

6 Incidence of CV Events in Subjects With T2DM vs the Nondiabetic CAD Population

7 PPAR-g Agonists: Lipoprotein Effects

8 PROactive: Time to Secondary CV Composite End Point

9 FDA Statistical Review and Evaluation Meta-analysis of Pioglitazone

10 CV Events With PPAR-g Agonists

11 Genes Uniquely Regulated by the TZDs

12 Pioglitazone Induces IkBa Protein Expression In Vivo in a PPAR-a-Dependent Manner

13 The Concept of Dual PPAR-a/g Agonists

14 Effect of Muraglitazar on Composite CV Endpoints

15 Effect of Tesaglitazar on Serum Creatinine and Glomerular Filtration

16 SYNCHRONY: Effect of Aleglitazar vs Pioglitazone on A1c

17 SYNCHRONY: Effect of Aleglitazar vs Pioglitazone on LDL-C and HDL-C

18 ALECARDIO: Aleglitazar in Patients With T2DM and ACS

19 Program Summary

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