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Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome 

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Presentation on theme: "Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome "— Presentation transcript:

1 Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome  Mutiu Idowu Kazeem, Musbau Adewunmi Akanji, Musa Toyin Yakubu  Pathophysiology  Volume 22, Issue 4, Pages (December 2015) DOI: /j.pathophys Copyright © 2015 Elsevier B.V. Terms and Conditions

2 Fig. 1 Effect of oral administration of polyphenols from Z. officinale on the Insulin concentration in normal and streptozotocin-induced diabetic rats. Values are mean±S.E.M. of 8 rats per group. Bars carrying different superscripts are significantly different (p<0.05). CON: Normal Control, DBT: Diabetic Control, Free: Diabetic rats treated with free polyphenol extract, Bound: Diabetic rats treated with bound polyphenol extract, GBN: Diabetic rats treated with glibenclamide. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2015 Elsevier B.V. Terms and Conditions

3 Fig. 2 Photomicrograph of pancreatic sections of control and diabetic rats treated with polyphenols from Z. officinale (A) The pancreas is normal with no injury. (B) Destruction of the β-cell and pancreatic tissue architecture. (C) Regeneration of the β-cell. (D) Regeneration of small islet. (E) Near normal architecture of the pancreas with no visible damage. (Haematoxylin and eosin ×400). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2015 Elsevier B.V. Terms and Conditions

4 Fig. 3 Photomicrograph of kidney sections in control and diabetic rats treated with polyphenols from Z. officinale (A) The kidney is normal with no glomerular injury. (B) Total destruction of the glomerular architecture and appearance of glycogen deposit. (C) Restoration of the normal glomerular architecture. (D) Near restoration of glomerular architecture. (E) No glycogen deposit. (Periodic acid Schiff ×400). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2015 Elsevier B.V. Terms and Conditions


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