Download presentation
Presentation is loading. Please wait.
1
Some DCs Are “B”etter Immunity
Brian Ruffell, Lisa M. Coussens Immunity Volume 38, Issue 4, Pages (April 2013) DOI: /j.immuni Copyright © 2013 Elsevier Inc. Terms and Conditions
2
Figure 1 Intratumoral Antigen Presentation by CD11b+Ly6C+ DCs following Anthracycline-Induced ICD Anthracyclines induce ICD in sensitive cells, leading to release of ATP and recruitment of CD11b+Ly6C+ inflammatory monocytes via purinergic receptors. ATP also promotes DC differentiation, and following antigen uptake and activation via the interaction between HMGB1 and TLR4, CD11b+Ly6C+ DCs remain in the tumor and are able to promote a local CD8+ T cell response. Immunity , DOI: ( /j.immuni ) Copyright © 2013 Elsevier Inc. Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.