1. A systems medicine approach for personalized chronotherapeutics.
A systems medicine approach for personalized chronotherapeutics. Individual patient data—such as measurements of circadian biomarkers, gene polymorphism, patient general characteristics, or disease history—are input into the systems medicine algorithm that computes personalized chrono-infusion schemes. The algorithm is developed through a multiscale pipeline integrating mathematical and experimental investigations in cell culture, in laboratory animals, and in patient populations. Results in multiple cell lines, animal strains, and patient subgroups allow for the reliable design of the personalization framework.
Annabelle Ballesta et al. Pharmacol Rev 2017;69:
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