Download presentation
Presentation is loading. Please wait.
Published byBlanche Holt Modified over 6 years ago
1
Re-analysis of epidemiologically linked tuberculosis cases not supported by IS6110- RFLP-based genotyping A. Martín, J. Iñigo, F. Chaves, M. Herranz, M.J. Ruiz-Serrano, E. Palenque, E. Bouza, D. García de Viedma Clinical Microbiology and Infection Volume 15, Issue 8, Pages (August 2009) DOI: /j x Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions
2
FIG. 1. Microepidemics showing cases matched using molecular techniques. N, number of cases involved in each microepidemic; RFLP, restriction fragment length polymorphism. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions
3
FIG. 2. Linked pairs initially considered not supported by the molecular analysis. The figure shows the number identifying each linked pair, the patients involved, the number of isolates available (I.A.) for analysis from independent specimens, the restriction fragment length polymorphism (RFLP), spoligotype, and the Mycobacterial interspersed repetitive unit (MIRU) patterns. MIRU alleles with differences between the cases involved are highlighted in bold. For case , who was infected with two clonal variants, both alleles are shown. Pairs are grouped as follows according to the redistribution in different interpretation categories after the refined molecular re-analysis: (a) proved linked pairs after identifying a laboratory error, (b) proved linked pairs for which a molecular match had been established after second-line genotyping, (c) pairs with partial molecular differences in second-line genotyping, and (d) pairs with marked molecular differences in second-line genotyping. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions
4
FIG. 3. Summary of the re-analysis of the 44 pairs initially considered discrepant using molecular data. From the total number of pairs in each panel, the number of pairs that involved household contacts is also indicated. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.