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Gadolinium deposition in nephrogenic systemic fibrosis: An examination of tissue using synchrotron x-ray fluorescence spectroscopy Whitney A. High, MD, MEng, James F. Ranville, PhD, Mariah Brown, MD, Tracy Punshon, PhD, Antonio Lanzirotti, PhD, Brian P. Jackson, PhD Journal of the American Academy of Dermatology Volume 62, Issue 1, Pages (January 2010) DOI: /j.jaad Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 1 Mapping of relative concentrations of gadolinium longitudinally through a biopsy specimen of skin and soft tissue using synchrotron x-ray fluorescence spectroscopy revealed greatest deposition to occur in areas of fibrosis and hypercellularity, including within widened subcuticular septae. Journal of the American Academy of Dermatology , 38-44DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 2 Mapping of relative concentrations of gadolinium longitudinally in a biopsy specimen taken from patient with a more deep-seated variant of nephrogenic systemic fibrosis revealed greatest deposition to correspond to areas of hypercellularity and fibrosis. Journal of the American Academy of Dermatology , 38-44DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 3 Two-dimensional mapping around an eccrine gland and duct (A) demonstrated gadolinium deposition (B) to colocalize to areas of calcium (C) and zinc (D) deposition. Journal of the American Academy of Dermatology , 38-44DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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