1. RBR Ubiquitin Transfer: Not Simply an “Open” and “Closed” Case?
Karen M. Dunkerley, Gary S. Shaw 
Structure 
Volume 25, Issue 6, Pages (June 2017)
DOI: /j.str
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2. Figure 1
Structure of the RBR E3 Ligase HHARI Bound to the UbcH7∼Ub Conjugate
(A) A cartoon structure of the HHARI/UbcH7∼Ub complex (Dove et al., 2017) showing the association of UbcH7 with the RING1 domain and “open” conformation of the conjugated Ub (∼Ub).
(B) As in (A) but with ∼Ub in the analogous position observed in the NEDD4L/UbcH5b∼Ub complex (PDB: 3UGB). The arrow indicates an additional C-terminal helix in the UBA-L domain that is not observed in apo-HHARI structures.
(C) As in (A) with the ∼Ub replaced by that observed in the HOIP/UbcH5b∼Ub complex (PDB: 5EDV). The arrow indicates the observed Ub binding region at the N terminus of the RING2/Rcat domain (Dove et al., 2016).
Structure  , DOI: ( /j.str )
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